UNDER CONSTRUCTION – THANK YOU FOR YOUR PATIENCE
Joshua Sodicoff, B.S.E.
Joshua Sodicoff, B.S.E.
Department: Computational Medicine and Bioinformatics
BIO: In my current role, I am developing a methodology for cell type deconvolution of heterogeneous tissue for application to large scale spatial transcriptomic data collected on the murine brain. Determination of the distributions of both well characterized and novel types identified with scRNA-seq data will allow for integration with physiological data and inference on the impact of present fine tissue structures. More generally, I am interested in the spatial organization of biological structure as a manifestation of the emergent properties of small-scale biochemical and genetic interactions with applications in microbial ecology and evolutionary biology.
Xin Luo,Ph.D.
Department: Computational Medicine and Bioinformatics
BIO: My current research direction is about cell-cell communication and single-cell analysis. I will work on single-cell multi-modality integration in the future. Spatial single-cell analysis interests me a lot as spatial-level cell-cell communication has a lot to explore.
Mohammad Faisal Syed, Ph.D.
Mohammad Faisal Syed, Ph.D.
Department of Neurosurgery; Department of Cell and Developmental Biology; and Rogel Cancer Center, University of Michigan Medical School
Research Interests: We will use multimodal approaches; single-cell RNA-seq (scRNA-seq), mass cytometry (cytometry time-of-flight (CyTOF) immune phenotyping), and multiplex imaging to discover the spatial phenotypic signatures of the tumor microenvironment in brain tumors.
Yuji Mishina, Ph.D.
Yuji Mishina, Ph.D.
William R. Mann Professor of Dentistry, School of Dentistry
Dr. Mishina’s laboratory is interested in functions of BMP signaling during bone development/remodeling and craniofacial development. Several specific projects include mechanisms of how osteoclasts regulate osteoblast functions in a spatiotemporal manner as a downstream event of BMP signaling, cell fate specification mechanisms in cranial neural crest cells towards chondrogenic lineage, impacts of nanofibrous biomaterials as stem cell niche, identification of crossover points between BMP signaling and mechanosensing for bone homeostasis, and investigation of cellular mechanisms of heterotopic bone formation to identify therapeutic options. We fully utilize genetically modified mouse lines in combination of cellular and molecular approaches including single-cell omics to uncover the above mentioned mechanisms.
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