Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer

Rupp B, Owen S, Ball H, Smith KJ, Gunchick V, Keller ET, Sahai V, Nagrath S.
Abstract: As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into potentially targetable regions for cancer treatment. Circulating tumor cells (CTCs) represent an especially aggressive subset of cancer cells……

Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes

Abstract: The epidermis is the outermost layer of skin. Here, we used targeted lipid profiling to characterize the biogeographic alterations of human epidermal lipids across 12 anatomically distinct body sites, and we used single-cell RNA-Seq to compare keratinocyte gene expression at acral and nonacral sites. We demonstrate that acral skin……

September 2022

Keap1 moderates the transcription of virus induced genes through G9a-GLPand NFκB p50 recruitment.

Burns VE, Kerppola TK.Immunology. 2022 Sep;167(1):105-121. doi: 10.1111/imm.13527. Epub 2022 Jul 7.PMID: 35751391
 

August 2022

BASS: multi-scale and multi-sample analysis enables accurate cell type clustering and spatial domain detection in spatial transcriptomic studies.

Li Z, Zhou X.
Genome Biol. 2022 Aug 4;23(1):168. doi: 10.1186/s13059-022-02734-7.

PMID: 35927760

 

August 2022

Dissecting the Heterogeneity of Human Thoracic Aortic Aneurysms Using Single-Cell Transcriptomics.

Mizrak D, Feng H, Yang B.
Arterioscler Thromb Vasc Biol. 2022 Aug;42(8):919-930. doi: 10.1161/ATVBAHA.122.317484. Epub 2022 Jun 16.

PMID: 35708028 Review.

July 2022

Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer.

Rupp B, Owen S, Ball H, Smith KJ, Gunchick V, Keller ET, Sahai V, Nagrath S.
Int J Mol Sci. 2022 Jul 16;23(14):7852. doi: 10.3390/ijms23147852.

PMID: 35887203 Free PMC article.

 

July 2022

Spatial Transcriptomics as a Novel Approach to Redefine Electrical Stimulation Safety.

Whitsitt QA, Koo B, Celik ME, Evans BM, Weiland JD, Purcell EK.
Front Neurosci. 2022 Jul 19;16:937923. doi: 10.3389/fnins.2022.937923. eCollection 2022.

PMID: 35928007 Free PMC article.

July 2022

Statistical analysis of spatially resolved transcriptomic data by incorporating multiomics auxiliary information

Li Y, Zhou X, Cao H.
Genetics. 2022 Jul 30;221(4):iyac095. doi: 10.1093/genetics/iyac095.

PMID: 35731210

July 2022

Joint dimension reduction and clustering analysis of single-cell RNA-seq and spatial transcriptomics data.

Liu W, Liao X, Yang Y, Lin H, Yeong J, Zhou X, Shi X, Liu J.
Nucleic Acids Res. 2022 Jul 8;50(12):e72. doi: 10.1093/nar/gkac219.

PMID: 35349708 Free PMC article.

September 2021

Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcriptition.

Burns VE, Kerppola TK.J Immunol. 2021 Sep 1;207(5):1437-1447. doi: 10.4049/jimmunol.2100355. Epub 2021 Aug 16.PMID: 34400522 Free PMC article.