Dr. Yuji Mishina

School of Dentistry

Dr. Mishina’s laboratory is interested in functions of BMP signaling during bone development/remodeling and craniofacial development. Several specific projects include mechanisms of how osteoclasts regulate osteoblast functions in a spatiotemporal manner as a downstream event of BMP signaling, cell fate specification mechanisms in cranial neural crest cells towards chondrogenic lineage, impacts of nanofibrous biomaterials as stem cell niche, identification of crossover points between BMP signaling and mechanosensing for bone homeostasis, and investigation of cellular mechanisms of heterotopic bone formation to identify therapeutic options. We fully utilize genetically modified mouse lines in combination of cellular and molecular approaches including single-cell omics to uncover the above mentioned mechanisms.


Recent Publications:

Novel approaches for periodontal tissue engineering.Swanson WB, Yao Y, Mishina Y.Genesis. 2022 Sep;60(8-9):e23499. doi: 10.1002/dvg.23499. Epub 2022 Sep 10.PMID: 36086991 Review.

Roles of osteoclasts in alveolar bone remodeling.Omi M, Mishina Y.Genesis. 2022 Sep;60(8-9):e23490. doi: 10.1002/dvg.23490. Epub 2022 Jun 27.PMID: 35757898 Review.

Expression of Cre recombinase in chondrocytes causes abnormal craniofacial and skeletal development.Qi S, Wang Y, Wei X, Xie D, Mohsen R, Hsieh YL, Mishina Y, Liu F.Transgenic Res. 2022 Jun;31(3):399-411. doi: 10.1007/s11248-022-00308-8. Epub 2022 May 8.PMID: 35526258

Enhanced BMP signaling through ALK2 attenuates keratinocyte differentiation.Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y, Komatsu Y.Biochem Biophys Res Commun. 2022 Nov 12;629:101-105. doi: 10.1016/j.bbrc.2022.09.014. Epub 2022 Sep 10.PMID: 36116371

Activation of AcvR1-Mediated Signaling Results in Semilunar Valve Defects.Syed S, Rajderkar S, Mann JM, Hawkins T, Wu B, Zhou B, Sugi Y, Mishina Y, Kaartinen V.J Cardiovasc Dev Dis. 2022 Aug 16;9(8):272. doi: 10.3390/jcdd9080272.PMID: 36005436 Free PMC article.