under construction

Recent interesting non-SCSAP publications

November 14, 2021

Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
David W McKellar 1Lauren D Walter 2Leo T Song 1Madhav Mantri 3Michael F Z Wang 3Iwijn De Vlaminck # 4Benjamin D Cosgrove # 5

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been hampered by the poor sampling of rare and transient cell states that are critical for muscle repair, and do not inform the spatial context that is important for myogenic differentiation. Here, we demonstrate how large-scale integration of single-cell and spatial transcriptomic data can overcome these limitations. ……Please see link for more information. 

October 29, 2021

Single-Cell Proteomic Analysis Dissects the Complexity of Tumor Microenvironment in Muscle Invasive Bladder Cancer
Chao Feng 1 2 3Xi Wang 1 2 4Yuting Tao 1 2 3Yuanliang Xie 1 2 5Zhiyong Lai 1 2Zhijian Li 1 2Jiaxin Hu 1 2Shaomei Tang 1 2Lixin Pan 1 2Liangyu He 1 2 6 7Qiuyan Wang 1 2 4Tianyu Li 1 2 6 7Zengnan Mo 1 2 6 7

Muscle invasive bladder cancer (MIBC) is a malignancy with considerable heterogeneity. The MIBC tumor microenvironment (TME) is highly complex, comprising diverse phenotypes and spatial architectures. The complexity of the MIBC TME must be characterized to provide potential targets for precision therapy. Herein, an integrated combination of mass cytometry and imaging mass cytometry was used to analyze tumor cells, immune cells, and TME spatial characteristics of 44 MIBC patients. We detected tumor and immune cell clusters with abnormal phenotypes. ….Please see link for more information

Member publications – coming soon