University of Michigan Single Cell Spatial Analysis Program and Vizgen
are partnering to sponsor a grant program to enable UM researchers an opportunity to win access to a
MERSCOPE Platform Single-cell Spatial Analysis Project to advance their research

The Vizgen MERSCOPE Platform is the first and only commercial solution for MERFISH technology, enabling massively multiplexed, error-robust, single-cell in situ transcriptomic imaging. The MERSCOPE platform solution includes reagents, the MERSCOPE instrument, and software to streamline the full process from sample to high-quality MERFISH data.

MERFISH (Multiplexed error-robust fluorescence in situ hybridization) is a spatially resolved single-cell transcriptome profiling technology developed in the lab of Dr. Xiaowei Zhuang, Harvard University. MERFISH combines the power of single-cell transcriptomics with spatial biology by directly visualizing and counting up to a billion RNA transcripts from 100’s to > 10,000 genes across 1cm2 tissue slices with single-cell resolution. This is achieved by massively multiplexing single-molecule fluorescence in situ hybridization (smFISH) through error robust barcoding, combinatorial labeling, and sequential imaging. By building upon the gold standard of RNA quantification, smFISH, MERFISH leads the nascent spatial genomics field with unmatched sensitivity and detection efficiency. This enables mapping the molecular, cellular, and functional composition of biological systems with preserved spatial context, providing insight into the biologically relevant organization of tissues in health and disease.

  • Winners must be or become members of SCSAP
  • Application deadline is March 14th, 2023

  • The Grant Program winner will be announced in April 2023.

    Other Conditions:

  • Tissue type- Human

  • Samples need to be available within no more than 2 months

The Grant Program winner will receive:

  • Full lab project resulting in MERFISH measurement of a 500 gene panel on 2 MERSCOPE Slides (Human FFPE Tissues) through the Single Cell Spatial Analysis Program

  • Access to the Vizgen Gene Panel Portal to design their custom gene panel

  • Access to Vizgen MERSCOPETM Visualizer analysis and visualization software

  • Data analysis consultation with Vizgen team